β-Carbolines: A Privileged Scaffold for Modern Drug Discovery

β-Carbolines: A Privileged Scaffold for Modern Drug Discoveryprovides a summary of methods for the synthesis of various natural products engineered with the diverse β-carboline scaffold and their biological evaluation.

β-Carboline and its derivatives have generated considerable interest in recent years for their versatile properties in chemistry and pharmacology. This is due to their ability to act as agonists to benzodiazepine receptors, hydroxy serotonin receptors, and intercalate into DNA, to inhibit CDK, Topisomerase, and monoamine oxidase enzymes. Their pharmacological properties include anxiolytic, hypnotic, anticonvulsant, antiviral, antiparasitic and antimicrobial attributes. This book provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carboline scaffold and their biological evaluation.

Features:

• Focuses on the different application and therapies of the B-carbolines
• Provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carbolines
• Discusses methods of biological evaluation of B-Carbolines
• Explores different chemical transformations occurring with synthesis using B Carbolines.
• Covers both heterocyclic synthesis and multicomponent synthesis related to β carboline.

Prof. Keshav Lalit Ameta is working as a Professor at the Department of Applied Chemistry, School of Applied material Sciences, Central University of Gujarat, Gandhinagar, India. Prior to the current position, he has served at Sardar Patel University, Vallabh Vidyanagar, Gujarat and Mody University of Science and Technology, Lakshmangarh, Rajasthan. Prof. Ameta has published over 100 research articles in the field of organic chemistry and catalysis in the journals of international repute. He received his master and doctorate degree in Organic Chemistry from M. L. Sukhadia University, Udaipur, Rajasthan, India. He has vast experience of teaching both graduate and postgraduate level students. His research area involves synthesis, characterization and biological evaluation of different sized bioactive heterocyclic systems. In addition, to this he has keen interests in heterogeneous catalyzed organic synthesis and photocatalysis.