Advances in Hemophilia Treatment: From Genetics to Joint Health

This book offers a comprehensive and state of the art overview of hemophilia management by reviewing all most recent advances and cutting edge information in this fast evolving field. As hemophilia patients are often affected by joint problems it also provides clear guidance on the surgical treatment of musculo-skeletal manifestations.

The first part is devoted to the disease’s pathophysiology (differentiating hemophilia A and B), genetics, pharmacotherapy - including replacement and non-replacement therapy - and gene therapy, as well as quality of life issues - also related to hemophilia carriers. The second part is then focused on joint problems, ranging from joint health assessment and pain control to surgical treatment of acute hemarthrosis and hemophilic arthropathy, i.e. radiosynovectomy, total joint arthroplasty and arthroscopic joint debridement.

Written by experts drawn from leading institutions involved in treatment of hemophilia and related joint problems, this book offers a valuable resource to hematologists, orthopedic surgeons, rehabilitation physicians, radiologists, and pharmacy researchers.

E. Carlos Rodríguez-Merchán is a Specialist in Orthopedic Surgery and ＂Emeritus＂ Consultant Orthopedic Surgeon currently working at the Department of Orthopedic Surgery, La Paz University Hospital, Madrid, Spain. Dr. Rodríguez-Merchán graduated from Complutense University with a degree in Medicine and Surgery in 1974, and subsequently completed a PhD in Medicine and Surgery. He is a former Associate Professor of Orthopedics at the Autonomous University of Madrid. Dr. Rodríguez-Merchán is the author of more than 300 articles in peer-reviewed PubMed-cited journals, as well as 11 books.