Premarin Vaginal Cream is used in the vagina to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse. Premarin (conjugated estrogens) Vaginal Cream is clinically proven to relieve moderate to severe painful intercourse due to menopause. In a clinical study, just 0.5 g of Premarin Vaginal Cream twice a week significantly relieved moderate to severe painful intercourse due to menopause after 12 weeks of treatment. Individual results may vary. Premarin Vaginal Cream helps rebuild vaginal tissue and make intercourse more comfortable.